Paninoteca Orfeo
Mon: ClosedTue–Thu: 12:00-04:30Fri–Sun: 18:30-05:30
Late-night specialist. No set menu — choose from dozens of ingredients. Also pasta and Nutella crepes.
Via Oderisi da Gubbio, 141, 00154 Roma RM, Italy
Rome's most celebrated late-night sandwich institution: open from noon until 4:30am on weekdays, and from 6:30pm until 5:30am on weekends. No fixed menu — choose from dozens of fillings (chicken, beef, turkey, artichokes, sun-dried tomatoes, mushrooms, eggplant) and design your own panino. Also serves pasta and sweet Nutella crepes. The go-to for anyone awake (or still awake) in central Rome after midnight.